CL572, a potent agonist of Toll-like receptor 2/7, as a novel latency-reversing agent
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چکیده
منابع مشابه
Synthetic Toll Like Receptor-4 (TLR-4) Agonist Peptides as a Novel Class of Adjuvants
BACKGROUND Adjuvants serve as catalysts of the innate immune response by initiating a localized site of inflammation that is mitigated by the interactions between antigens and toll like receptor (TLR) proteins. Currently, the majority of vaccines are formulated with aluminum based adjuvants, which are associated with various side effects. In an effort to develop a new class of adjuvants, agonis...
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Toll like receptor (TLR), one of the key functions of innate immune system, can recognize not only exogenous pathogen-associated molecular patterns, namely PAMPs, but also endogenous molecules created upon tissue injury, sterile inflammation and degeneration. Endogenous TLR ligands are called as damage-associated molecular patters (DAMPs), including endogenous molecules released by activated an...
متن کاملDiversity of Toll-like Receptor Genes and Helicobacter Pylori Infections: A Meta-Analysis Study
Background and Aims: Several studies have shown that host genetic factors can be associated with the risk of developing Helicobacter pylori infections. Therefore, we evaluated the most prevalent toll-like receptors (TLRs) polymorphisms in Helicobacter pylori positive subjects and their possible role in susceptibility to Helicobacter pylori infections. Materials and Methods: Using related keywo...
متن کاملAnti-radiation damage effect of polyethylenimine as a toll-like receptor 5 targeted agonist
A number of agents are now available for use in protecting against ionizing radiation. These radiation-protective agents, however, have many adverse effects. Efforts have been made to develop new radiation-protective agents for medical application. Here, we investigated whether a compound, polyethylenimine (PEI), which activates Toll-like receptor 5 (TLR5)-mediated NF-kB signaling pathways, cou...
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ژورنال
عنوان ژورنال: Journal of Virus Eradication
سال: 2015
ISSN: 2055-6640
DOI: 10.1016/s2055-6640(20)31332-7